It truly is eliminated predominantly by hepatic metabolism (mostly CYP3A4) and is particularly converted to an Lively metabolite with properties similar to the mum or dad, sildenafil. Each sildenafil and the metabolite have terminal 50 % lives of about four hours.

If Viagra doesn’t give you the results you want, talk to your doctor. They could advise a higher dose of Viagra or a different medication.

The protection and efficacy of mixtures of VIAGRA with other PDE5 Inhibitors, like REVATIO or other pulmonary arterial hypertension (PAH) treatments that contains sildenafil, or other remedies for erectile dysfunction haven't been researched.

You'll want to explain to your medical doctor about any health care problems you might have and any medicines you are taking before beginning Viagra. Your medical doctor can figure out if this drug is good for you.

NO then activates the enzyme guanylate cyclase, which leads to elevated levels of cyclic guanosine monophosphate (cGMP), manufacturing easy muscle mass leisure within the corpus cavernosum and allowing for inflow of blood.

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Right after both oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (somewhere around eighty% of administered oral dose) and to a lesser extent from the urine (roughly 13% with the administered oral dose).

Viagra is employed to treat erectile dysfunction (impotence) in Adult males. An additional manufacturer of sildenafil is Revatio, which happens to be made use of to deal with pulmonary arterial read more hypertension and boost physical exercise potential in Guys and girls. This website page consists of particular information for Viagra, not Revatio.

VIAGRA could impact how other medicines perform, together with other medicines may affect the way VIAGRA will work triggering Negative effects. In particular convey to your healthcare supplier if you take any of the following:

Disclaimer: Healthline has made every exertion to produce sure that all facts is factually right, detailed, and updated. Even so, this informative article shouldn't be made use of as a substitute for your information and abilities of the certified healthcare Qualified. You should usually consult your medical doctor or A different Health care Specialist ahead of using any medication.

Medical professionals should go over with people the greater threat of NAION in people who have previously knowledgeable NAION in a single eye. Physicians should also focus on with sufferers the increased chance of NAION among the overall inhabitants in individuals which has a “crowded” optic disc, Though evidence is inadequate to aid screening of prospective people of PDE5 inhibitor, like VIAGRA, for this uncommon affliction [see WARNINGS AND Safety measures and ADVERSE REACTIONS].

Grapefruit and grapefruit juice may possibly communicate with sildenafil and bring about undesirable Negative effects. Stay clear of the use of grapefruit products and solutions though using sildenafil.

There exists a potential for cardiac chance of sexual exercise in people with preexisting cardiovascular disease. Hence, therapies for erectile dysfunction, together with VIAGRA, shouldn't be typically Employed in men for whom sexual activity is inadvisable due to their underlying cardiovascular status.

Although the interaction in between other protease inhibitors and sildenafil has not been examined, their concomitant use is anticipated to enhance sildenafil concentrations.